Jasmina Marušić*1 Edhem Hasković2 Adnan Mujezinović1 Harun Adilović3 Vedran Đido4

1 Department of Health Care, Faculty of Medicine, University of Zenica, Zenica, Bosnia and Herzegovina

2 Department of Biology, Faculty of Science, University of Sarajevo, Sarajevo, Bosnia and Herzegovina

3 Public Institution Cantonal Hospital Zenica, Zenica, Bosnia and Herzegovina

4 Department of Public Health, Faculty of Health Studies, University of Sarajevo, Sarajevo, Bosnia and Herzegovina

*Corresponding author: Jasmina Marušić, Department of Health Care, Faculty of Medicine, University of Zenica, Zenica, Bosnia and Herzegovina, email: jasminavele@gmail.com

DOI: https://doi.org/10.17532/dzn.2023.028

Abstract

Introduction: As a result of research conducted globally, experts continue to extensively study the long-term consequences that SARS-CoV-2 infection can have on patients, as well as the factors contributing to severe outcomes. The aim of this study was to investigate the values of basic biochemical and hematological parameters in patients with fatal outcomes of SARS-CoV-2 infection, as well as to determine the combination of hematological and biochemical parameters that contribute to the progression of SARS-CoV-2 infection. The examined parameters were correlated with age and gender distribution of patients with fatal outcomes of SARS-CoV-2 infection. Methods: The study represents a retrospective study of patients hospitalized at the Cantonal Hospital Zenica from February to April 2021, focusing on the biochemical and hematological parameters of subjects with confirmed presence of SARS-CoV-2 virus using the RT-PCR method, who were hospitalized at the Cantonal Hospital Zenica. Results: Of the 250 deceased subjects in the sample, females comprised the relative majority with 53.6%. Among the examined parameters, hemoglobin, MCH, and MCH were significantly lower in females compared to males, while males had significantly higher values of urea, creatinine, and troponin. The average age of the patients was 74 years, and with aging, the values of erythrocytes, hemoglobin, and troponin increased. Troponin showed a statistically significant positive correlation with age, as well as with urea and creatinine.

Conclusion: We can conclude that hemoglobin, urea, creatinine, and troponin are parameters that can be considered to contribute to the progression of SARS-CoV-2 infection. These parameters can be useful for assessing disease severity and prognosis in patients infected with SARS-CoV-2 virus.

Keywords: Covid-19, biochemical parameters, hematological parameters, age, gender, mortality